Assistancecirculation should be administered by infusion volume and vasopressors, if necessary. Convulsions should be treated with intravenous benzodiazepines and recurrence of seizures can be treated with phenobarbital. In case of severe depression of the central nervous order soma C WALLACE 2103 Daly City system, reflexes, respiratory protection may be compromised and tracheal intubation should be considered for airway protection and respiratory support. The following types of treatment have been order soma C WALLACE 2103 Daly City used successfully by an overdose deméprobamate, a metabolite of carisoprodol: activated charcoal (oral or nasogastric tube), forced diuresis, peritoneal dialysis and hemodialysis (carisoprodol is dialyzable). Careful monitoring of urine output is necessary and overhydration should be avoided. Observed relapse due to the absorption of delayed gastric emptying incomplete. For more information on the management of a carisoprodol overdose, contact a poison control center. Carisoprodol Tablets, USP are available about 350 mg, white tablets for oral administration. Carisoprodol is a white crystalline powder, low odor and a characteristic bitter taste. It is slightly soluble in water, soluble in alcohol, chloroform and acetone, and its solubility is practically independent of pH. Chemically, carisoprodol is N-isopropyl-2-methyl-2-propyl-1 ,3-propanediol dicarbamate and molecular formula is C12H24N2O4, order soma C WALLACE 2103 Daly City with a molecular weight of 260.33. The structural formula is: Other Ingredients Carisoprodol tablets, USP include croscarmellose hidrogenadosaceite vegetables, hypromellose, magnesium stearate and microcrystalline cellulose. The mechanism of action of carisoprodol in relieving discomfort associated with musculoskeletal disorders neuropathy has not been clearly identified.
In animal studies, muscle relaxation order soma C WALLACE 2103 Daly City induced by carisoprodol is associated with altered interneuronal activity in the spinal cord order soma C WALLACE 2103 Daly City and descending reticular formation of the brain. Carisoprodol is a skeletal muscle relaxant, centrally acting, not directly relax skeletal muscles. A metabolite of carisoprodol, meprobamate, has anxiolytic and sedative. The degree to order soma C WALLACE 2103 Daly City which these properties of meprobamate contribute to the safety and efficacy of carisoprodol is unknown. The pharmacokinetics of carisoprodol and meprobamate metabolite were studied in a crossover study of 24 healthy order soma C WALLACE 2103 Daly City subjects (12 men and 12 women) who received a single dose of 350 mg (see Table 2) carisoprodol. Cmax of meprobamate was 2.5 ± 0.5 g / ml (mean ± SD) after administration of single doses of 350, carisoprodol, which is about 30% of the Cmax of meprobamate (approximately order soma C WALLACE 2103 Daly City 8 g / ml) after administration of a single dose of 400 mg of meprobamate. Absorption The absolute bioavailability of carisoprodol has not been determined. The median time to maximum plasma concentration (Tmax) of carisoprodol was approximately 1.5 to 2 hours. Concomitant administration of a high-fat meal, and carisoprodol (order soma C WALLACE 2103 Daly City 350 mg) had no effect on the pharmacokinetics of carisoprodol. Therefore, carisoprodol can be taken with or without food.
Metabolism: The major pathway of carisoprodol metabolism is the liver by CYP2C19 to order soma C WALLACE 2103 Daly City form meprobamate. This enzyme exhibits genetic polymorphism (see Patients with Reduced CYP2C19 Activity below).
Elimination: Carisoprodol is eliminated by order soma C WALLACE 2103 Daly City two-way non-renal failure and with a terminal elimination half-life of about 2 hours. The half-life of meprobamate is approximately order soma C WALLACE 2103 Daly City 10 hours. Gender: The exposure of carisoprodol is higherwomen than in men (about 3.050% on a weight-adjusted).
The overall exposure of meprobamate is comparable order soma C WALLACE 2103 Daly City between male and female subjects. Patients with reduced CYP2C19 activity: Carisoprodol should be used with caution in patients with reduced CYP2C19 activity. Published studies indicate order soma C WALLACE 2103 Daly City that patients who are CYP2C19 poor metabolizers have a 4 times increase in order soma C WALLACE 2103 Daly City exposure to carisoprodol, and concomitant exposure to 50% decrease compared with normal CYP2C19 metabolizers meprobamate. The prevalence of poor metabolizers in Caucasians and African Americans is about 35% and in Asians is approximately 1.520%. The long-term studies in animals have not been conducted to evaluate the carcinogenic potential of carisoprodol. Carisoprodol is not formally evaluated for genotoxicity. In published studies, carisoprodol was order soma C WALLACE 2103 Daly City mutagenic in the in vitro test of order soma C WALLACE 2103 Daly City mouse lymphoma cells in the absence of metabolizing enzymes, but was not mutagenic in the presence of metabolizing enzymes.
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